This summary is not the rule. The rule text controls.
Here's a plain English summary:
When someone is charged with multiple crimes in one case, or when multiple people are charged together in the same case, sometimes this setup can unfairly hurt one side. Maybe the evidence against one defendant makes the jury think badly of another defendant who had nothing to do with it. Or maybe piling all the charges together confuses the jury or makes the defendant look guilty just because there are so many charges.
This rule says that if either the defendant or the prosecution can show this kind of unfair harm is happening, the court has to step in and fix it. The judge can split the charges into separate trials, or separate the defendants so each person gets their own trial. The judge can also order any other solution that makes the process fair again.
The main point is that a trial has to be fair. If combining charges or combining defendants makes it harder for someone to get a fair shake, the court must take action to correct that problem.